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A trial of outpatient chemotherapy for recurrent head and neck tumors

✍ Scribed by Andrew T. Huang; Virgil S. Lucas; Sandra G. Baughn; T. Boyce Cole

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 338 KB
Volume: 45
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19800415)45:8<2038::aid-cncr2820450808>3.0.co;2-1

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✦ Synopsis

A four-drug combination chemotherapy (bleomycin-methotrexate-vinblastine-CCNU) had been used in 38 evaluable patients with recurrent squamous cell carcinoma of the head and neck region on an outpatient basis. A large number of these patients had carcinoma of the oral cavity (45% of total). Nineteen patients (50%) responded to this regimen with a greater than or equal to 50% regression of their measured tumors. The median survival of all patients was 34 weeks. There was one chemotherapy-related death and the overall toxicity was mild. This convenient regimen can be considered a useful alternative to more aggressive therapy.

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