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A transgenic mouse model of the ubiquitin/proteasome system

✍ Scribed by Lindsten, Kristina; Menéndez-Benito, Victoria; Masucci, Maria G; Dantuma, Nico P


Book ID
109911114
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
972 KB
Volume
21
Category
Article
ISSN
1087-0156

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## Abstract Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease caused by an abnormally expanded CAG repeat in the HD gene. Ubiquitylated aggregates containing mutant huntingtin protein in neurons are hallmarks of HD. Misfolded mutant huntingtin monomers, oligom