A Top-Down Approach to a Complex Natural System: Protein Folding
β Scribed by Alan Levin
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 233 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1122-1151
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π SIMILAR VOLUMES
Developing methodology for analyzing complex protein mixtures in a rapid fashion is one of the most challenging problems facing analytical biochemists today. Recent advances in mass spectrometry for the analysis of intact proteins (i.e. the top-down approach) show great promise for rapid protein ide
We have developed SPICKER, a simple and efficient strategy to identify near-native folds by clustering protein structures generated during computer simulations. In general, the most populated clusters tend to be closer to the native conformation than the lowest energy structures. To assess the gener