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A thermospray liquid chromatography/mass spectrometry method for analysis of human urine for the major malondialdehyde-guanine adduct

✍ Scribed by Jajoo, Hemant K.; Burcham, Philip C.; Goda, Yukihiro; Blair, Ian A.; Marnett, Lawrence J.

Book ID: 127106764
Publisher: American Chemical Society
Year: 1992
Tongue: English
Weight: 649 KB
Volume: 5
Category: Article
ISSN: 0893-228X
DOI: 10.1021/tx00030a022

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## Abstract The major adduct of malondialdehyde with guanine, M~1~G, was measured in human urine from non‐smoking healthy individuals. M~1~G is a mutagenic DNA lesion and a terminal product of lipid peroxidation __in vivo__ that may be implicated in cancer related to lifestyle and diet. On the basi