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A theory of virus-induced demyelination in the Landry-Guillain-Barré syndrome

✍ Scribed by Jay S. Pepose

Publisher
Springer
Year
1982
Tongue
English
Weight
312 KB
Volume
227
Category
Article
ISSN
0340-5354

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✦ Synopsis

The Landry-Guillain-Barré syndrome (LGBS) is a demyelinating disorder of the peripheral nervous system frequently preceded by infection with common viruses. Most prevalent among these agents are herpesviruses, particularly Epstein-Barr virus (EBV) and cytomegalovirus (CMV). The specific role played by antecedent viral infection in the pathogenesis of the LGBS remains obscure. In this regard, recent studies of Marek's disease (MD) neuropathy, an avian herpesvirus-induced experimental model for the LGBS, may provide insight. The autoimmune pattern of demyelination seen in MD neuropathy is histopathologically indistinguishable from that seen in the LGBS. In this paper, a comprehensive theory is discussed regarding the pathogenetic mechanisms that may be operative in the LGBS.

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Marek's disease: A natural model for the
Marek's disease: A natural model for the Landry-Guillain-Barré syndrome
✍ Dr. Jack G. Stevens; Jay S. Pepose; Margery L. Cook 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 714 KB

The early lesions of Marek's disease in chickens are indistinguishable from those of the Landry-Guillain-BarrC syndrome in human beings. Because of these similarities, and since the etiological agent (a herpesvirus) is known, Marek's disease can be meaningfully exploited as a model of the Landry-Gui