A theoretical study of discriminating parameters in metabolic resistance to insecticides

✍ Scribed by Chalvet-Monfray, Karine; Belzunces, Luc P.; Auger, Pierre

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 319 KB
• Volume: 52
• Category: Article
• ISSN: 1526-498X
• DOI: 10.1002/(sici)1096-9063(199804)52:4<354::aid-ps728>3.0.co;2-6

✦ Synopsis

In the case where resistance to an insecticide is associated with increased metabolism of the insecticide, it should not be concluded that the resistance is due only to the increased metabolism (i.e. metabolic hypothesis).

Here, we study theoretically the pharmacokinetic consequences of a resistance mechanism due to increased metabolism. We consider two cases : treatment with the initial dose applied to the susceptible strain and the treatment with the D 0 initial dose with a [ 1, applied to the resistant strain. We show the condi-aD 0 , tions for which the metabolism hypothesis is conceivable. The time q, from which the mortality of the susceptible strain is signiÐcantly higher than that of the resistant strain, is an important parameter in determining the validity of the metabolic hypothesis. The more q increases, the more the conditions are favourable to this hypothesis. Our work suggests an approach to test the metabolic hypothesis from experimental results. 1998