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A Template for Stabilization of a Peptide α-Helix: Synthesis and Evaluation of Conformational Effects by Circular Dichroism and NMR

✍ Scribed by Austin, Richard E.; Maplestone, Rachael A.; Sefler, Andrea M.; Liu, Kim; Hruzewicz, Witold N.; Liu, Corey W.; Cho, Ho S.; Wemmer, David E.; Bartlett, Paul A.


Book ID
126853386
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
420 KB
Volume
119
Category
Article
ISSN
0002-7863

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In the native structure of hen egg white lysozyme (HEL) , the amino acid sequence 87-97 (HEL 87-97) forms an amphiphilic helix, with hydrophilic residues in the sequence directed toward the solvent. A synthetic version of the HEL 87-97 sequence (with the cysteine corresponding to position 94 of HEL