A tandem CC → TT transition in the p53 gene of a breast cancer
✍ Scribed by Hagen Blaszyk; Arndt Hartmann; Lester E. Wold; Jennifer J. Schroeder; Renee M. McGovern; Steve S. Sommer; John S. Kovach
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 275 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1059-7794
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Several retrospective studies have suggested p53 gene mutation as an adverse prognostic indicator in breast cancer patients, based on a selective growth advantage of p53 mutant cancer cells and their presumed resistance to current adjuvant therapy regimens. A cohort of 90 Caucasian midwestern breast
The p53 tumor suppressor gene has proven to be one of the genes most often mutated in human cancers. It involves mainly point mutations leading to amino acid substitutions in the central region of the protein which impairs normal functions. Analysis of the mutational events that target the p53 gene
The prognostic significance of p53 gene abnormalities was investigated in 9 I9 primary breast-cancer patients. p53 expression and tumour-cell proliferation fraction determined by MIB-I count, p53 exon 5 and 6 mutations and HER-Z/neu oncogene amplification were detected by immunohistochemistry, PCR-S