To date, 2 major breast cancer and/or ovarian cancer predisposition genes have been identified. However, a significant proportion of families with multiple cases of breast cancer cannot be explained by mutations in the BRCA1 and BRCA2 genes, 1 especially in the Nordic populations. [2][3][4] In addit
Familial breast cancer. Approaching the isolation of a susceptibility gene
β Scribed by Barbara L. Weber; Kenneth J. Abel; Larry C. Brody; Wendy L. Flejter; Settara C. Chandrasekharappa; Fergus J. Couch; Sofia D. Merajver; Francis S. Collins
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 781 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Here we report the study on BRCA1 and BRCA2 mutations in 12 Thai breast and/or ovarian cancer families and 6 early-onset breast or breast/ovarian cancer cases without a family history of cancer. Five distinct rare alterations were identified in each gene: four introducing premature stop codons, one
Duchenne muscular dystrophy (DMD) is an X-linked degenerative disorder of muscle, caused by gross rearrangements by the dystrophin gene in two-thirds of cases. The remaining one-third of patients may carry more subtle mutations that are difficult to detect because of the large size and complexity of
## Abstract Estrogen has been suggested to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE). To examine this hypothesis, we carried out a multigenic caseβcontrol study of 469 incident breast cancer patients and 740 healthy controls to de
## Abstract Vascular endothelial growth factorβA (VEGFβA) plays an important role in tumour angiogenesis and cancer progression. __VEGF__ gene variation may influence VEGF levels and therefore cancer susceptibility and progression. We studied the role of __VEGF__ single nucleotide polymorphisms and