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A systematic review of dual targeting in HER2-positive breast cancer

✍ Scribed by Kümler, Iben; Tuxen, Malgorzata K.; Nielsen, Dorte Lisbet

Book ID
121366409
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
492 KB
Volume
40
Category
Article
ISSN
0305-7372

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## Abstract Chromosomal instability (CIN) is a common cause of tumour heterogeneity and poor prognosis in solid tumours and describes cell–cell variation in chromosome structure or number across a tumour population. In this article we consider evidence suggesting that CIN may be targeted and may in