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A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease

✍ Scribed by Joosten, Antoine; Decroocq, Camille; de Sousa, Julien; Schneider, Jérémy P.; Etamé, Emile; Bodlenner, Anne; Butters, Terry D.; Compain, Philippe


Book ID
121839961
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
660 KB
Volume
15
Category
Article
ISSN
1439-4227

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## Abstract A series of __O__‐alkyl iminoxylitol derivatives was synthesized and evaluated as β‐glucocerebrosidase (GCase) inhibitors. This structure–activity study shows a dramatic influence of the position of the alkyl chain (α‐C1, O2, O3, or O4) on human GCase inhibition. Remarkably, 1,2‐shift o