A series of ethyl 3-alkyl-4-oxochroman-3-carboxylates 5 was synthesized and some representative reactions were attempted on these compounds. The fTrst step of the synthesis was the condensation of diethyl alkylsodiomalonates on aryloxymethyl chlorides. Hydrolysis of one eater group and treatment wit
A synthetically useful conversion of benzoic acid derivatives to 4-alkylphenols and 4-alkyl-3-carbalkoxyphenols
β Scribed by Schultz, Arthur G.; Harrington, Roger E.; Macielag, Mark; Mehta, Parag G.; Taveras, Arthur G.
- Book ID
- 124168411
- Publisher
- American Chemical Society
- Year
- 1987
- Tongue
- English
- Weight
- 404 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Ethyl 2βaminoβ3βmethoxycarbonylβ4βoxoβ2βpentenoate (3) reacts with hydroxylamine or hydrazines to give isoxazole and pyrazole orthoβdicarboxylic acid esters 4 and 5, respectively. Partial hydrolysis of diesters 4 and 5 afforded the corresponding dicarboxylic acid monoesters 6 and 7. Ami
The synthesis and biological evaluation of 4-(4-(alkyl- and phenylaminocarbonyl)benzoyl)benzoic acids (4a-4d) as non-steroidal inhibitors of steroid 5 alpha-reductase are described. The compounds were tested in vitro for inhibitory activity toward rat and human 5 alpha-reductase isozymes 1 and 2 at