Synthesis of ethyl 3-alkyl-4-oxochroman-3-carboxylates and their conversion to some derivatives

✍ Scribed by Bernard Loubinoux; Jean-Luc Colin; Brigitte Antonot-Colin; Lucien Lalloz

• Book ID: 104205037
• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 476 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)89934-8

✦ Synopsis

A series of ethyl 3-alkyl-4-oxochroman-3-carboxylates 5 was synthesized and some representative reactions were attempted on these compounds. The fTrst step of the synthesis was the condensation of diethyl alkylsodiomalonates on aryloxymethyl chlorides. Hydrolysis of one eater group and treatment with thionyl chloride afforded the mono acyl halides which were cyclixed by means of aluminium chloride.