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A synthetic bombesin-analogue acting as specific bombesin receptor antagonist

✍ Scribed by C. Severi; C. Anania; D.H. Coy; R.T. Jensen; L. Boschero; V. Erspamer; G. Delle Fave

Book ID
114075780
Publisher
Elsevier Science
Year
1988
Weight
59 KB
Volume
20
Category
Article
ISSN
0031-6989

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(D-Phe12) bombesin and substance P analo
(D-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists
✍ Zul Merali; Carol A. Merchant; Jacqueline N. Crawley; David H. Coy; Peter Heinz- πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 676 KB

The potency of synthetic bombesin (BN) analogues with D-Phe12 substitutions and substance P analogues was investigated in the rat CNS. (D-Phe12,Leu14)BN, (D-Phe12)BN and (Tyr4,D-Phe12)BN inhibited binding to rat brain slices with IC50 values of approximately 2 microM. Similarly, spantide inhibited b