𝔖 Bobbio Scriptorium
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A Synthesis of the Welwistatin Core§

✍ Scribed by Lauchli, Ryan; Shea, Kenneth J.


Book ID
115472057
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
65 KB
Volume
8
Category
Article
ISSN
1523-7060

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A concise synthesis of the cortistatin c
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We describe a concise and convergent route to the core matrix of the cortistatin steroidal alkaloids. The salient features of the synthesis are the Snieckus cascade methodology and the Masamune alkylative dearomatization. This chemistry lends itself to a total synthesis of the cortistatins and to th