A concise synthesis of the cortistatin core

✍ Scribed by Mingji Dai; Samuel J. Danishefsky

• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 295 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.09.018

✦ Synopsis

We describe a concise and convergent route to the core matrix of the cortistatin steroidal alkaloids. The salient features of the synthesis are the Snieckus cascade methodology and the Masamune alkylative dearomatization. This chemistry lends itself to a total synthesis of the cortistatins and to the development of a SAR program based on diverted total synthesis.