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A concise synthesis of the steroidal core of clathsterol

✍ Scribed by Rigang Cong; Yihua Zhang; Weisheng Tian


Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
205 KB
Volume
51
Category
Article
ISSN
0040-4039

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A concise synthesis of the cortistatin c
✍ Mingji Dai; Samuel J. Danishefsky πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 French βš– 295 KB

We describe a concise and convergent route to the core matrix of the cortistatin steroidal alkaloids. The salient features of the synthesis are the Snieckus cascade methodology and the Masamune alkylative dearomatization. This chemistry lends itself to a total synthesis of the cortistatins and to th