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A synthesis of potential new antiarrhythmic agents

✍ Scribed by Tariq Javed; Ghassan F. Shattat

Publisher
Journal of Heterocyclic Chemistry
Year
2005
Tongue
English
Weight
75 KB
Volume
42
Category
Article
ISSN
0022-152X

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✦ Synopsis

N-Ethylation of substituted ethyl 1H-indole-2-carboxylates with iodoethane and potassium carbonate gave substituted ethyl 1-ethyl-1H-indole-2-carboxylates. The later compounds on treatment with a range of aryl amines with varying structural complexity, gave the desired ethyl 1H-indole-2-carboxamide analogues.

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## Abstract Ibutilide fumarate, racemic N‐[4‐[4‐(ethyl‐n‐heptylamino)‐1‐hydroxybutyl]phenyl]methanesulfonamide hemifumarate, and artilide, the R‐(+)‐enantiomer of N‐[4‐[4‐(di‐n‐butylalmino)‐1‐hydroxybutyl]‐phenyl]methanesulfonamide hemifumerate, are under clinical investigation as Class III antiarr