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A synthesis of cis-α-unsaturated nitriles by kinetically controlled decarboxylation

✍ Scribed by John Fairhurst; David C. Horwell; Graham H. Timms

Book ID
104224427
Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
120 KB
Volume
16
Category
Article
ISSN
0040-4039

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✦ Synopsis

The Doebner condensation of aldehydes with cyanoacetic acid gives a cis/trans mixture of a,B-unsaturated nitriles containing a high proportion of the trans isomer'. The purification of the minor c%s isomer has been accomplished by Inefficient and laborious fractional distillation or crystallisation'~'. However, Knoevenagel reaction gives the intermediate a-cyano-acrylic acids in high yicld'r3. It has been suggested4 that in these compounds the carboxylic acid group lies exclusively bans to the

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