A sultone approach to the C(1)–C(18) moiety of pamamycin-607

✍ Scribed by Heiko Bernsmann; Roland Fröhlich; Peter Metz

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 167 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00659-6

✦ Synopsis

A highly advanced enantiomerically pure C(1)±C( 18) precursor of the larger fragment of the macrodiolide pamamycin-607 has been synthesized. The stereotriad C(7)±C( 9) between the two heterocyclic rings of the target was generated using a diastereoselective hydroboration controlled by minimization of allylic 1,3-strain.