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A stereocontrolled synthetic route to the C1C18 subunit of pamamycin-607

✍ Scribed by Sung Ho Kang; Joon Won Jeong


Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
78 KB
Volume
43
Category
Article
ISSN
0040-4039

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A highly advanced enantiomerically pure C(1)±C( 18) precursor of the larger fragment of the macrodiolide pamamycin-607 has been synthesized. The stereotriad C(7)±C( 9) between the two heterocyclic rings of the target was generated using a diastereoselective hydroboration controlled by minimization o