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A subchronic inhalation study with unleaded petrol in rats

✍ Scribed by Adolf Vyskočil; Miloslav Tušl; Jindřich Obršál; Karel Zaydlar

Book ID
102293775
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
268 KB
Volume
8
Category
Article
ISSN
0260-437X

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✦ Synopsis

The effect of intermittent 2 months' exposure to 2 g/m' unleaded petrol on the hypothalamo-pituitary-thyroidadrenal system was evaluated by measuring hypothalamic noradrenaline (NA), serum corticosterone (CS), thyroxine (T,) and adrenal catecholamine (CA) levels in male rats. Serum CS and adrenal CA were increased and hypothalamic NA was decreased by exposure. No changes were observed in serum T4. Exposure induced an increase in spleen, kidney, liver and lung weights; weights of adrenals and hypothalamus were not changed. All the petrol-induced effects depended on the length of exposure. Rats exposed to petrol gained less weight than controls. The results suggest a non-specific stress response in the rat.

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