✍ Scribed by C. N. M. Bakker; F. M. Kaspersen; A. van Langevelde; J. A. Oosterhuis; E. K. J. Pauwels
No coin nor oath required. For personal study only.
Chloroquine can be iodinated with radioactive iodine in radiochemical yields 60‐75% with chloramine‐T or H~2~O~2~/lactoperoxidase. With both methods a rather complex mixture of labelled products is formed. The yield and ratios of the labelled products depend upon the chloroquine‐concentration, the amount of carrier iodide present and in the case of the chloramine‐T method, the chloramine‐T concentration. With the chloramine‐T method the main product is 3‐iodochloroquine, with H~2~O~2~/lactoperoxidase an unidentified iodinated chloroquine‐derivative, probably a dimer, is the main labelled product. With chloramine‐T products such as 3‐chlorochloroquine and deethylchloroquine are formed in mass amounts.
📜 SIMILAR VOLUMES
The kinetics of the eledrophilic substitution of several trialkyltin chlorides by iodine monochloride are presented. Rate constants have been determined at four different temperatures and the activation parameters A, En, and AS"= are calculated. A mechanism is proposed involving charge-transfer as t
## Abstract The use of a double‐blind therapeutic study to determine the effects of chloroquine on rheumatoid arthritis demonstrated antirheumatic properties of this drug. The criteria of Lansbury were successfully combined with other objective measurements to provide data of statistical validity.