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A study on the correlation between estrogen receptor, progesterone receptor and tamoxifen binding sites in human breast cancer tissues

✍ Scribed by Yoko Imanaka; Seikichi Tsuboi; Norio Kohno; Yoichi Saitoh


Book ID
112755722
Publisher
Springer
Year
1987
Tongue
English
Weight
560 KB
Volume
17
Category
Article
ISSN
1436-2813

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## Abstract We show that flavonoids positively regulate type‐II estrogen‐binding site (type‐ll EBS) levels both in MCF‐7 (ER‐positive) and in MDA‐MB231 (ER‐negative) breast‐cancer cells. Type‐ll EBS were measured by a whole‐cell assay at 4°C for 2.5 hr using [^3^H]‐estradiol as tracer. In both cell