A study of tobacco carcinogenesis, LIII: carcinogenicity of N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mink (Mustala vison)
✍ Scribed by Nils Koppang; Abraham Rivenson; Hans K. Dahle; Dietrich Hoffmann
- Book ID
- 117468388
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 480 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0304-3835
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## Abstract ## BACKGROUND In the United States, Blacks who smoke cigarettes have a higher mean blood concentration of the nicotine metabolite cotinine than White smokers. It has not been determined whether there are racial differences in the exposure to the cigarette smoke carcinogen 4‐(methylnitr
The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c