The use of a nonlinear absorption model
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Dr V. K. Piotrovskij; Z. Kállay; M. Gajdoš; M. Geryková; T. Trnovec
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Article
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1993
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John Wiley and Sons
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English
⚖ 739 KB
A two-compartment disposition model of ascorbic acid (AA) pharmacokinetics with saturable and time-constrained intestinal absorption was developed. The model was fitted to pharmacokinetic data obtained after oral administration to nine healthy volunteers of two effervescent dosage forms differing in