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A study of muscarinic receptor heterogeneity with weak antagonists

โœ Scribed by Abraham Fisher; Yona Grunfeld; Marta Weinstock; Simon Gitter; Sasson Cohen

Book ID
118322108
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
624 KB
Volume
38
Category
Article
ISSN
0014-2999

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๐Ÿ“œ SIMILAR VOLUMES

Molecular connectivity study of muscarin
Molecular connectivity study of muscarinic receptor affinity of acetylcholine antagonists
โœ Lemont B. Kier; Lowell H. Hall ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 539 KB

A correlation between three molecular connectivity indexes and the muscarinic receptor affinity of 104 acetylcholine antagonists was found. Analysis of structure from these indexes reveals not only the importance of the onium and the bulky portions of the molecule but also their virtual independence