๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

A study of angiogenesis factors from five different sources using a radioimmunoassay

โœ Scribed by S. Shahabuddin; S. Kumar; D. West; F. Arnold


Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
653 KB
Volume
35
Category
Article
ISSN
0020-7136

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โœฆ Synopsis


Abstract

The use of a radioimmunoassay (RIA) demonstrated that angiogenic factors from human and animal tumours, normal bovine retinas, myocardial infarcts, synovial fluid from patients with joint diseases and wound fluid shared common antigenic determinants. Values for angiogenesis factors expressed as ฮผg Walker tumour TAF/mg protein varied from 0.8 (wound fluid) to 207 (myocardial infarct). Activated macrophages produced an angiogenic factor which did not crossreact. Normal tissue extracts which were nonโ€angiogenic by the chicken chorioallantoic membrane assay also failed to crossโ€react in the RIA. The antigenic similarity of angiogenic factors from such a wide variety of sources suggests that, in order to minimize therapeutic side effects, it would be best to use angiogenic agonists and antagonists locally.


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