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A study of 4-substituted 5,5-diaryl oxazolidin-2-ones as efficacious chiral auxiliaries

✍ Scribed by Colin L. Gibson; Karen Gillon; Stuart Cook

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
251 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A series of three 5,5-diaryl substituted oxazolidin-2-ones (diphenyl, dinaphthyl and ditolyl) have been prepared and shown to be particularly effective chiral auxiliaries to afford high yields and diastereoselectivities for alkylation and azidations of their N-acyl derivatives. The 5,5-ditolyl oxazolidin-2-one proved to be particularly efficacious in terms of diastereoselectivity, yield and sc~lubility.

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ChemInform Abstract: Highly Effective an
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