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A study of 2,4,6-trinitrotoluene inhibition of benzo[a]pyrene uptake and activation in a microbial mutagenicity assay

✍ Scribed by K.S. Washburn; K.C. Donnelly; H.J. Huebner; R.C. Burghardt; T.C. Sewall; L.D. Claxton


Book ID
117248615
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
119 KB
Volume
44
Category
Article
ISSN
0045-6535

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3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a