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A structure-activity study on the bradykinin B1antagonist desArg10-HOE 140: The alanine scan

✍ Scribed by Claudia Galoppini; Riccardo Patacchini; Stefania Meini; Stefania Viganò; Mariella Tancredi; Laura Quartara; Antonio Triolo; Carlo A. Maggi; Paolo Rovero

Book ID
105576554
Publisher
Springer Netherlands
Year
1999
Tongue
English
Weight
433 KB
Volume
6
Category
Article
ISSN
1573-3149

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Synthesis of the bradykinin B1antagonist
Synthesis of the bradykinin B1antagonist [desArg10]HOE 140 on 2-chlorotrityl resin
✍ Paolo Rovero; Stefania Viganò; Stefano Pegoraro; Laura Quartara 📂 Article 📅 1996 🏛 Springer Netherlands 🌐 English ⚖ 327 KB

This paper describes the synthesis of the bradykinin B l antagonist [desArgl°]HOE 140 (D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-OH) by the solid-phase method. This synthesis is predicted to be a difficult one because the Cterminal sequence D-Tic-Oic, when linked to the resin, could easily undergo an