A Structural Perspective on Respiratory Complex I: Structure and Function of NADH:ubiquinone oxidoreductase

✍ Scribed by Rouslan G. Efremov, Leonid Sazanov (auth.), Leonid Sazanov (eds.)

• Publisher: Springer Netherlands
• Year: 2012
• Tongue: English
• Leaves: 280
• Edition: 1
• Category: Library

✦ Synopsis

The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.

✦ Table of Contents

Front Matter....Pages i-x
Front Matter....Pages 1-1
Structure of Complex I....Pages 3-21
On the Mechanism of the Respiratory Complex I....Pages 23-59
Iron–Sulfur Clusters in Complex I....Pages 61-79
Current Topics of the Inhibitors of Mitochondrial Complex I....Pages 81-98
My Fifty Years Association with Complex I Study....Pages 99-105
Front Matter....Pages 107-107
The Evolutionary Relationship Between Complex I and [NiFe]-Hydrogenase....Pages 109-121
Recruitment of the Antiporter Module – A Key Event in Complex I Evolution....Pages 123-143
Front Matter....Pages 145-145
Characterization of Bacterial Complex I (NDH-1) by a Genetic Engineering Approach....Pages 147-169
Cellular Consequences of mtDNA-Encoded Mutations in NADH:Ubiquinone Oxidoreductase....Pages 171-189
Front Matter....Pages 191-191
The Assembly of Human Complex I....Pages 193-217
Complexes I in the Green Lineage....Pages 219-244
Front Matter....Pages 245-245
Supramolecular Organization of the Respiratory Chain....Pages 247-277
Back Matter....Pages 279-286

✦ Subjects

Biomedicine general; Biochemistry, general; Protein Structure; Membrane Biology; Molecular Medicine