A Structural Model for TCR Recognition of the HLA Class II Shared Epitope Sequence Implicated in Susceptibility to Rheumatoid Arthritis

HLA Class ii sequence polymorphisms and

HLA Class ii sequence polymorphisms and susceptibility to rheumatoid arthritis in greeks. the hla–drβ shared-epitope hypothesis accounts for the disease in only a minority of greek patients

✍ Kyriaki A. Boki; Gabriel S. Panayi; Robert W. Vaughan; Alexandros A. Drosos; Har 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 633 KB

Objective. In Northern Europeans, rheumatoid arthritis (RA) is strongly associated with a relatively conserved pentapeptide sequence of HLA-DRP found notably in the HLA-DR4 subtypes Dw4 and Dw14 and in DRl. A previous serologic study of HLA class I1 polymorphism in a Greek population with RA failed