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A Strategy to Discover Inhibitors of O-Linked Glycosylation

โœ Scribed by Gross, Benjamin J.; Swoboda, Jonathan G.; Walker, Suzanne

Book ID
125333374
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
78 KB
Volume
130
Category
Article
ISSN
0002-7863

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A sensitive mass spectrometric method for the specific identification of 0-glycosylation sites in glycopeptides is presented. Reductive j-elimination liberates a peptide containing a specifically modified amino acid at the former site of carbohydrate attachment. Mass spectrometry is used to determin