A Strategy for Designing a Peptide Probe for Detection of β-Amyloid Oligomers
✍ Scribed by Yang Hu; Baihao Su; Dr. Chung-Sei Kim; Michael Hernandez; Prof. Agueda Rostagno; Prof. Jorge Ghiso; Prof. Jin Ryoun Kim
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 527 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1439-4227
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## Abstract Amyloid β peptide (Aβ) fibril formation is widely believed to be the causative event of Alzheimer’s disease pathogenesis. Therapeutic approaches are therefore in development that target various sites in the production and aggregation of Aβ. Herein we present a high‐throughput screening
DNA could readily associate with the aggregated forms of the -amyloid peptides (1-40) and (25-35), giving rise to a shift in the electrophoretic mobility of DNA. As a result, DNA was retained at the top of a 1% agarose gel. In contrast, the electrophoretic mobility of DNA was little influenced by