The introduction of thalidomide, lenalidomide, and bortezomib has changed the way that multiple myeloma (MM) is treated and has greatly improved survival outcomes. These novel agents are often used in combination with conventional drugs, such as dexamethasone, to optimize clinical responses; however
A strategic framework for novel drug development in multiple myeloma
✍ Scribed by Kenneth C. Anderson; Alison L. Hannah; Richard Pazdur; Ann T. Farrell
- Book ID
- 108675270
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 650 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0007-1048
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Drug‐eluting stents have proven superior to bare metal stents with lower restenosis rates. Local delivery of drugs from these stents is achieved in most cases with the help of biostable polymer coatings. However, since the polymer coating remains in the body well after all the drug is r
## Abstract Tartrate‐resistant acid phosphatase isoform‐5b (TRACP‐5b), a new marker reflecting osteoclast activity, and osteoprotegerin (OPG) were measured in 121 patients with multiple myeloma (MM) at diagnosis, and in 63 of them during pamidronate administration, to define their correlation with
## Abstract 14q32 translocations [t(14q)] represent critical but not universal events in multiple myeloma (MM). Gains of chromosome arms 1q, 9q, and 11q (+1q, +9q, and +11q) have recently been identified as frequent aberrations in this disease, but their pathogenetic significance remains unclear. W
## Abstract 1q rearrangement is a remarkably frequent secondary chromosomal change in both non‐Hodgkin's lymphoma (NHL) and multiple myeloma (MM), where it is associated with tumor progression. To gain insight into 1q rearrangement‐associated disease mechanisms, we used fluorescence in situ hybridi