Development of a novel biocompatible polymer system for extended drug release in a next-generation drug-eluting stent

✍ Scribed by Kishore Udipi; Mingfei Chen; Peiwen Cheng; Kevin Jiang; Diane Judd; Alejandra Caceres; Robert J. Melder; Josiah N. Wilcox

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 332 KB
• Volume: 85A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.31664

✦ Synopsis

Abstract

Drug‐eluting stents have proven superior to bare metal stents with lower restenosis rates. Local delivery of drugs from these stents is achieved in most cases with the help of biostable polymer coatings. However, since the polymer coating remains in the body well after all the drug is released, patients can potentially develop hypersensitivity to these polymers—leading to complications such as late‐stent thrombosis. It is therefore important that the polymers are designed to be biocompatible and well tolerated by the body. The polymer coatings are also expected to be robust and provide good control over elution of the desired drug. This paper describes the development of a unique, proprietary polymer blend system, specially designed to meet these requirements. Mutually compatible, free‐radical‐initiated elastomeric polymers were designed to provide a robust coating and offer a steady, sustained release of the highly hydrophobic drug zotarolimus over an extended period. The polymer blend system is also well tolerated by the hydrophilic environment in vivo, as demonstrated through porcine studies. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008