A Straightforward Synthesis of Pyrazolines and Pyrazoles: Palladium-Catalyzed Carbonylative Vinylation–Cyclocondensation Reactions of Aryl Halides

✍ Scribed by Xiao-Feng Wu; Helfried Neumann; Matthias Beller

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 431 KB
• Volume: 2011
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201100654

✦ Synopsis

Abstract

A novel consecutive one‐pot synthesis of pyrazolines and pyrazoles starting from simple aryl halides, styrenes, carbon monoxide, and hydrazines has been established. Palladium‐catalyzed carbonylative vinylation of aryl halides gave the corresponding chalcones, which are trapped in situ by addition of hydrazines.