𝔖 Bobbio Scriptorium
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A straightforward synthesis of L-isoserinal

✍ Scribed by Federico Junquera; Francisco L. Merchán; Pedro Merino; Tomas Tejero


Book ID
103405906
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
444 KB
Volume
52
Category
Article
ISSN
0040-4020

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Enantioselective synthesis of optically
✍ A. Solladie-Cavallo; N. Khiar 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 201 KB

KF-promoted addition of nitromethane on (-)-8-phenylmenthyl glyoxylate monohydrate affords, after one purification, optically pure (-1s isoserine in about 50% yield. Isoserine was found to inhibit several enzymes of serine metabolism in mammals and to interfer with panthotenic acid synthesis from D-