Tandem one-pot synthesis of ฮฑ-(aminometh
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Young Ok Ko; Yu Sung Chun; Youngmee Kim; Sung Jin Kim; Hyunik Shin; Sang-gi Lee
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Article
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2010
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Elsevier Science
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French
โ 668 KB
A novel tandem one-pot method for the synthesis of a-aminomethylene-c-butyrolactone derivatives has been developed through the regioselective epoxide opening reactions with the Blaise reaction intermediates, generated by the reaction of a Reformatsky reagent with nitriles. Formation of a modified Bl