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A stochastic model for the origin and treatment of tumors containing drug-resistant cells

✍ Scribed by A.J. Coldman; J.H. Goldie

Publisher
Springer
Year
1986
Tongue
English
Weight
938 KB
Volume
48
Category
Article
ISSN
1522-9602

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✦ Synopsis

A stochastic model for the chemotherapy of experimental tumors is presented. The focus of this model is on the presence of drug-resistant mura~ts and their in~uence on eventual treatment outcome. Equations are derived for the joint probability-generating function for the number of chemo-sensitive and chemo-resistant cells. The model is extended to two drugs and it is shown how the model may be used to make deductions regarding the optimum scheduling of therapy.

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