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A stereoselective synthesis of an α-substituted α-amino acid as a substructure for the construction of myriocin

✍ Scribed by Miroslava Martinková; Jozef Gonda; Jana Špaková Raschmanová; Juraj Kuchár; Jozef Kožíšek


Book ID
116909633
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
996 KB
Volume
23
Category
Article
ISSN
0957-4166

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Facile stereoselective synthesis of γ-su
✍ Martin Smrcina; Pavel Majer; Eva Majerová; Tatiana A. Guerassina; Michael A. Eis 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 459 KB

A lacile slereoselcctive melhod Ior the synthesis of y-substituted, y-mnino acids from of amino acids was developed. The key step of the procedurc is complete reduction of Ihe keto functionality of ot-~unino acyl Meldruln's acid by sodium acetoxyborohydride. The resulting amino alkyl Meldrum's acid