A State-of-the-Art Cyanation of Aryl Bromides: A Novel and Versatile Copper Catalyst System Inspired by Nature

✍ Scribed by Thomas Schareina; Alexander Zapf; Wolfgang Mägerlein; Nikolaus Müller; Matthias Beller

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 136 KB
• Volume: 13
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.200700079

✦ Synopsis

Abstract

A general protocol for the cyanation of aryl halides with the nontoxic cyanide source K~4~[Fe(CN)~6~] using copper catalysis and a ligand system based on 1‐alkylimidazoles is presented. The advantages of this system are the high selectivity, a unique substrate range, easy handling, and inexpensive reagents.