Cyclodextrins are a group of cyclic oligosaccharides with a ring, basket-like structure. These compounds are able to include several kinds of molecules into their internal cavity, leading to important modiÐcations of the properties of the guest compound. The interaction between b-cyclodextrin and t
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A Spectral and Molecular Dynamics Simulation Study ofβ-Cyclodextrin Inclusion Complexes with Solvatochromic Dyes Derived from Barbituric Acid
✍ Scribed by Francisco Jara; Carolina Mascayano; Marcos Caroli Rezende; Cristian Tirapegui; Alejandro Urzua
- Publisher
- Springer Netherlands
- Year
- 2006
- Tongue
- English
- Weight
- 289 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0923-0750
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The formation of complexes and the mode of binding to macrocyclic host molecules (a-and bcyclodextrins, CDs) of the nootropic drug CI-844 (3-phenoxypyridine sulphate, Warner-Lambert/Parke-Davis) were studied using NMR techniques (T-ROESY) complemented by molecular dynamics (MD) protocols which allow