A solvent induced mechanism for conformational change
β Scribed by Baker, Christopher M.; Grant, Guy H.
- Book ID
- 111957964
- Publisher
- Royal Society of Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 318 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1359-7345
- DOI
- 10.1039/b517868a
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π SIMILAR VOLUMES
Changes in the solvent dielectric properties are correlated with changes in polypeptide conformer populations. Gramicidin A, a peptide native to membrane environments, forms a variety of well deΓned dimeric conformations in relatively low dielectric organic solvents. However, changes in this environ
We have performed a 800 ps molecular dynamics simulation of bovine pancreatic trypsin inhibitor (BPTI) in water coupled to a pressure bath at 1, lO,OOO, 15,000, and 20,000 bar. The simulation reproduces quite well the experimental behavior of the protein under high pressure. The protein keeps its gl