A solid-phase synthesis of oligodeoxyribonucleotides and their analogues using deoxyribonucleoside phosphorobisdiethylamidite intermediates
β Scribed by Kazushige Yamana; Yoshitaka Nishijima; Hiroaki Ozaki; Hidehiko Nakano; Osamu Sangen; Takeo Shimidzu
- Publisher
- Elsevier Science
- Year
- 1991
- Weight
- 86 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0923-1137
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π SIMILAR VOLUMES
## The deoxyribonucleoside 3'-bis(l ,I ,I ,3,3,3-hexafluoro-2-propyl) phosphite units (3) are used in the chemical synthesis of oligodeoxyribonucleotides on solid supports. The new phosphite units (3) were prepared easily by reaction of nucleosides and tris-( I ,I ,I ,3,3,3-hexafluoro-2-propyl) phos
## Use of a derivatized support involving the 2,2'-diethyldithio-group 1 SllOWS the automated synthesis of oligodeoxyribonucleotide bearing acridine derivative (via nucleoside-3'acridinylphosphoramidite 2) or 3'phosphorothioate group (including the sulfurization step fOJ2 attachment of the first n