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A single-step competitive binding assay for mapping of single DNA molecules

✍ Scribed by Lena K. Nyberg; Fredrik Persson; Johan Berg; Johanna Bergström; Emelie Fransson; Linnea Olsson; Moa Persson; Antti Stålnacke; Jens Wigenius; Jonas O. Tegenfeldt; Fredrik Westerlund

Book ID
116302703
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
652 KB
Volume
417
Category
Article
ISSN
0006-291X

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Determination of haplotypes from single
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## Communicated by Richard Cotton Determining the haplotypes in a diploid individual is a major technical challenge in genetic studies of human complex traits. Here we report a method of molecular haplotyping by directly imaging multiple polymorphic sites on individual DNA molecules simultaneously