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A single-pot synthesis of 1,1,2-trisubstituted 1,2-dihydronaphthalenes in high enantiomeric purity

✍ Scribed by Mohamed K Mokhallalati; K.Raman Muralidharan; Lendon N Pridgen


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
305 KB
Volume
35
Category
Article
ISSN
0040-4039

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✦ Synopsis


A diastereoselective addition of Grignard reagents to nonracemic 2-(I-naphthyl)4-(4R)-phenyl-I.3-oxazolidines (1) followed by electrophilic trapping of the azaenokzte is described. This tandem addition

was perjormed in a single flask producing I, I,2-trisubstituted 1.2-dihydronaphthalenes 7 in excellent yields and high enontioselectivities.


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