A single-pot synthesis of 1,1,2-trisubstituted 1,2-dihydronaphthalenes in high enantiomeric purity
β Scribed by Mohamed K Mokhallalati; K.Raman Muralidharan; Lendon N Pridgen
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 305 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A diastereoselective addition of Grignard reagents to nonracemic 2-(I-naphthyl)4-(4R)-phenyl-I.3-oxazolidines (1) followed by electrophilic trapping of the azaenokzte is described. This tandem addition
was perjormed in a single flask producing I, I,2-trisubstituted 1.2-dihydronaphthalenes 7 in excellent yields and high enontioselectivities.
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## Abstract For Abstract see ChemInform Abstract in Full Text.