A single nucleotide polymorphism in the E-cadherin gene promoter − 160 C/A is associated with risk of nasopharyngeal cancer
✍ Scribed by Hela Ben Nasr; Bechr Hamrita; Mariem Batbout; Sallouha Gabbouj; Noureddine Bouaouina; Lotfi Chouchane; Karim Chahed
- Book ID
- 116348730
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 263 KB
- Volume
- 411
- Category
- Article
- ISSN
- 0009-8981
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E-cadherin plays a major role in intercellular adhesion, cell polarity and tissue architecture. We determined the relative risk of PCa associated with a previously reported C/A SNP at -160 bp relative to the transcription-start site of the E-cadherin gene promoter. Eighty-two PCa patients and 188 co
## Abstract The __E‐cadherin__ (__CDH1__) gene has been associated with prostate carcinogenesis. The C/A polymorphism −160 base pairs relative to the transcription start site has been shown to decrease gene transcription. We analyzed the association between this polymorphism and the risk of sporadi