A simplified model of serum growth hormone regulation in man

✍ Scribed by James C. Howard; Donald R. Young

• Publisher: Elsevier Science
• Year: 1970
• Tongue: English
• Weight: 422 KB
• Volume: 3
• Category: Article
• ISSN: 0010-4809
• DOI: 10.1016/0010-4809(70)90017-0

✦ Synopsis

A mathematical model of the glandular mechanism that controls the secretions of serum growth hormone in response to a glucose deficiency has been formulated. It was found that the concentration levels predicted by a linear model were in good agreement with experimental observations. Time domain analysis led to a number of interesting conclusions. By relating the mathematical parameters to physiological sensitivities, results were obtained that hopefully will be of value in diagnosis. Likewise, frequency domain analysis revealed a number of possible control mechanisms by which the pituitary gland controls the secretions of serum growth hormone. It is shown that defects in physiological control elements can deplete the available supply of growth hormone by permitting hormonal oscillations. A summary of the literature, which includes references to relevant publications on this subject, was presented previously (I I. A solution was obtained by digital computation. The numerical solution was 101